Syntheses of marine molecules
نویسندگان
چکیده
The enantioselective total syntheses of (-)(E)ybisabolene-8,9-epoxide, (+) (2S,6R)-2-bromo-13-chamigrene, and (+)-chamigrene, important intermediates in the biosynthesis of natural sesquiterpenoids isolated from algae of the genus Laurencia, are described. The compounds are synthesized with regio ñd stereocontrol by using simple forms of bridged intermediates. This represents a general strategy for the enantioselective construction of spirol5.5lundecane systems containing a chiral quaternary center. Our recent current progress towards the synthesis of the biologically active C25 tetronic acids isolated from sponges of the genus Ircinia is also described.
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